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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
The top drug-food interactions forCialisare also listed below by using the following information:
  • grapefruit: Though not a direct interaction, combining grapefruit with Cialis might worsen side effects like headaches or increase side effects like dizziness in sensitive individuals.

The popular erectile dysfunction medication Cialis has been discontinued by the manufacturer, but the product the doctor prescribes is still available in the UK.

According to the manufacturer, Cialis manufacturer GlaxoSmithKlinethe following information is present: ABOUT Cialis

This product is a generic version of Cialis; Cialis (tadalafil) is used to treat

men's and women's erectile dysfunction. For best results, the medicine must be taken as directed by your doctor. If you are taking

Direction for use by adults and children 12 years and over:

Take

One tablet

The recommended dose is one tablet a day. Cialis comes as a tablet (such as a pill) and a drink. Take it with a glass of water. Do not take it with milk or other dairy products.

Direction for use by adolescents (13 years and older:

Take one tablet a day. Do not exceed the recommended dose. Take the next dose at least 2 hours before or after taking Cialis. Do not take more than one dose in a 24-hour period. Cialis must be taken twice daily. If you take more than one dose at a time, it may increase your risk of side effects.

Adults:

The maximum recommended dosing frequency is once per day.

Warnings:

You should inform your doctor if you have:

  • kidnclaimed orrecently had heart surgery
  • heart failure
  • liver or kidney disease
  • seizures
  • trouble speaking
  • trouble uriatingly making love
  • seizure (convulsions)
  • sudden severe dizziness or fainting, should contact a doctor at no additional expense.

The manufacturer of Cialis acknowledges that this medicine contains some inactive ingredients, which may cause unwanted effects or affect the product’s safety. For these reasons, the manufacturer discontinued this product in the UK in June 2013.

The information below is provided for the information purpose and is not intended to replace the advice of a health professional. For further information about this product, please consult a UK pharmacist.

Do not take Cialis if youdo not have erectile dysfunction

Cialis

Active Ingredient

The active ingredient in Cialis is tadalafil (10

mg of). Cialis contains the active ingredient10M. The doctor prescribing Cialis does not know if the medicine is used for:

  • treat erectile dysfunction
  • treat symptoms of benign prostatic hyperplasia (BPH)
  • treat urinary symptoms of benign prostatic hyperplasia (BPH)

Cialis may cause dizziness or lightheadedness when you get up too quickly. Do not drive, use machinery, or do any activity that requires you to be alert.

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A new study has found that the erectile dysfunction drug Cialis (Tadalafil) can be safely used in the UK to treat erectile dysfunction.

The study, published in the New England Journal of Medicine, shows that the drug contains the active ingredient tadalafil. It is a phosphodiesterase type 5 (PDE5) inhibitor, which means that it increases blood flow to the penis and helps men with erectile dysfunction achieve and maintain an erection.

Cialis is not currently licensed to treat erectile dysfunction in the UK. The drug's active ingredient is tadalafil, which is a 5-alpha reductase inhibitor. This means that tadalafil can be used to treat erectile dysfunction in men who do not have erectile dysfunction.

Cialis is the only other ED medicine approved to treat erectile dysfunction in the UK. A recent study of more than 4,500 men with erectile dysfunction reported that the drug is safe to use in the UK for erectile dysfunction.

Tadalafil is the only ED medicine that has been approved to treat erectile dysfunction in the UK. The drug was originally developed as a treatment for high blood pressure. It was then discovered that a study showed that it can be safely used as a treatment for erectile dysfunction in men who do not have erectile dysfunction.

Dr Sarah M. Davies, a consultant urology and sexual medicine clinician at Imperial College London, who led the study, said: "The study shows that the drug may be useful in treating erectile dysfunction in men who do not have erectile dysfunction.

"We are really surprised that this is the only other ED medicine which has been shown to be safe to use.

"This is the first time that we have seen any study to show that a medicine which is not licensed to treat erectile dysfunction can be used safely.

"The results also demonstrate that this is the only ED medicine which is safe to use."

Dr Davies said: "The new study suggests that it may be the only ED medicine which is safe to use in the UK.

"It's important to note that this is not an approved medicine. It is a new drug which needs to be manufactured and supplied by the manufacturer to the UK market."

She said the study was "very promising" and it was "very encouraging" that there was "more research in the UK to further investigate the safety and efficacy of this new medicine".

She said: "This is the first time that we have seen any study to show that a medicine which is not licensed to treat erectile dysfunction can be used safely.

"This is the first time that we have seen any study to show that this is the only ED medicine which is safe to use.

She said: "This is the first time that we have seen any study to show that this is the only ED medicine which is safe to use.

"This is the first time that we have seen any study to show that it is the only ED medicine which is safe to use."

The latest study found that the drug contains the active ingredient tadalafil.

The study found that the drug contains the active ingredient tadalafil.

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